DES and familial dilated cardiomyopathy: We therefore repeated the analysis, only considering variants in genes classified as definitive DCM-gene (BAG3, DES, FLNC, LMNA, MYH7, PLN, RBM20, SCN5A, TNNC1, TNNT2, TTN) and genes with strong (DSP) or moderate evidence of involvement in DCM (ACTC1, ACTN2, JPH2, NEXN, TNNI3, TPM1, VCL) [22].