Genetically elevated levels of ABO (OR = 1.06, 95% CI: 1.04–1.08, P = 4.63E-13), LPA (OR = 1.21, 95% CI: 1.15–1.28, P = 9.60E-12), PCSK9 (OR = 1.36, 95% CI: 1.21–1.54, P = 2.30E-07), TGFB1 (OR = 1.31, 95% CI: 1.17–1.46, P = 2.54E-06), FGF5 (OR = 1.08, 95% CI: 1.04–1.11, P = 7.55E-06), VAMP5 (OR = 1.89, 95% CI: 1.41–2.52, P = 1.94E-05) were linked to an increased risk of MI, while higher levels of FES (OR = 0.65, 95% CI: 0.54–0.77, P = 5.38E-07) correlated with a lower risk (Supplementary Table S4). This evidence concerns the gene PCSK9 and myocardial infarction.