PCSK9 and coronary artery disorder: It was observed that CHD causal proteins, including TGFB1, FGF5, APOB, IL6R, PGF, PCSK9, LPA, and COL6A3, as well as four MI causal proteins, namely, TGFB1, FGF5, PCSK9, and LPA, exhibited significant interactions with existing drug targets (Fig. 5c, d).