Interleukin (IL)-6 in LLC-exosomes induced the lipidolysis of 3T3-L1 adipocytes by activating the signal transducer and activator of transcription 3 (STAT3) and promoting the cachexia process and the neutralization of extracellular IL-6 prevented the lipolysis effects of LLC-exosomes [80]. This evidence concerns the gene IL6 and Cachexia.