This mechanism was related to the miR155 in exosomes, and cancer cell-secreted miR-155 significantly downregulated phosphorylated PPARγ (p-PPARγ) and phosphorylated extracellular regulated protein kinases1/2 (p-ERK1/2) and remodeled metabolic process in skeletal muscle cells, leading to breast cancer-associated cachexia [95, 96]. This evidence concerns the gene PPARG and breast cancer.