TargetScan analysis and luciferase reporter assay showed that the genes related to the proliferation or differentiation, including GATA2, IGFBP4, MMP15, and C/EBPα, were all direct target genes of mir-425-3p, and the lung cancer cell-derived exosomes significantly downregulated the expression of GATA2, IGFBP4, MMP15, and C/EBPα in HPA-v cells [71]. This evidence concerns the gene MMP15 and lung cancer.