NT5E and neoplasm: In this work, we constructed a novel biomimetic photothermal nanodrug compositing with CD73 inhibitor α, β-methylene adenosine 5’diphosphate (AMPCP), black phosphorus quantum dots (BPQDs), chitosan nanogel, and aptamer modified erythrocyte membrane, which facilitates the adenosine inhibition of AMPCP to synergize with the photothermal effect of BPQDs to manipulate the tumor immune microenvironment, thus enhancing the subsequent immunotherapy of lung tumors.