Our findings demonstrated that knocking out c-Abl not only in PDGFRα-positive ECM-producing cells (c-AblMes−cKO mice) but also specifically in α-SMA-positive myofibroblasts (c-AblMyo−cKO mice), effectively alleviated renal fibrosis, which indicated that on the one hand, α-SMA positive myofibroblasts are the main cell type responsible for renal fibrosis. Here, ACTA1 is linked to renal fibrosis.