To gain insight into the role of c-Abl in regulating ECM-producing PDGFRα+ mesenchymal cells during renal fibrosis, an inducible knockout mouse model, PDGFRα-CreER;c-Ablflox/flox (hereafter referred to as c-AblMes−cKO), was generated and subsequently administered UUO injury (Fig. 1A). This evidence concerns the gene ABL1 and renal fibrosis.