To assess the potential benefits of specifically targeting c-Abl in renal myofibroblasts in established renal fibrosis, we generated an inducible, myofibroblast-specific knockout strain (α-SMA-CreER;c-Ablflox/flox, c-AblMyo−cKO) and administered tamoxifen 10 days after UUO. Here, ABL1 is linked to renal fibrosis.