Furthermore, DDX3 reported to attenuate cancer stem cell-like characteristics in HCC by interfering with DNMT3A binding and the induction of DNMT3A-mediated methylation on the promoter of tumor-suppressive miRNAs, thus facilitating the transcription of these miRNAs (i.e., miR-200b, miR-200c, miR-122, and miR-145)161. Here, DNMT3A is linked to hepatocellular carcinoma.