These results reveal that PLAGL2 directly interacts with the USP10 promoter region and functions as a transcriptional regulator of USP10, while USP10 deubiquitinates PLAGL2 to stabilize PLAGL2’s protein expression, both of which form a signaling loop to enhance HCC progress (Fig. 7h). The gene discussed is USP10; the disease is hepatocellular carcinoma.