Taken together, these findings suggest that chronic stress-induced epinephrine activates the ADRB2-c-Myc axis, thereby upregulating USP10 to stabilize PLAGL2, while PLAGL2 acted as a transcriptional regulator of USP10, forming a signaling loop to promote HCC progression (Fig. 9). The gene discussed is ADRB2; the disease is hepatocellular carcinoma.