EGFR and lung carcinoma: To explore resistance mechanisms in lung cancer cell lines other than A549, we constructed two series of EGFR mutants, namely, EGFR double mutants (19DM or RM) and C797S-containing EGFR triple mutants (19DMS or RMS), in human lung mucoepidermoid carcinoma H292 cells as well as human NSCLC PC-9 and H1975 cells (Supplementary Fig. 3a, c, e, and g).