We also observed that at an early time point (6 days post-injection), tumor tissues from mice implanted with Hepa1-6 cells mixed with GLS- or eIF5A-knockdown TAMs exhibited lower expression levels of HIF-1α, ARG1, CD80, and CD204 than did tumor tissues from mice implanted with Hepa1-6 cells mixed with TAMs (Fig. 6c, d). This evidence concerns the gene HIF1A and neoplasm.