NPPB and heart disorder: In this first cross-sectional study of associations of all bioactive NPs with cGMP, and each of their associations with recognised tissues targeted by these endocrine and paracrine factors, we find ANP and BNP are each independently associated with plasma cGMP adjusted for CNP but not cardiac risk factors, (the NP component model, Table 4) in subjects age 50 years free of overt heart disease.