Herein, we have used in silico-based screening to identify oxyresveratrol against HDAC2 protein, and therefore aimed to explore in vivo the ameliorative effects of ORV against memory deficits, lipid peroxidation, behavioural and HDAC expression in the hippocampus and cortex of STZ-induced AD rat model. This evidence concerns the gene HDAC9 and Alzheimer disease.