To date, Tyr394 in hLon’s N-terminal substrate binding domain is the most frequently modified amino acid, identified by more than 50 proteomic analyses performed on disease tissues originating in pancreatic carcinomas, colorectal cancer, lung cancer, atrial fibrillation, and ventricular tachycardia19. This evidence concerns the gene LONP1 and exocrine pancreatic carcinoma.