In this study, 3 sets of HNSCC samples were used for analysis, 33 prognostic MRGs were identified by LASSO analysis, and a prognostic model consisting of 8 MRGs (TGM2, STC1, SH2D3C, PIK3R3, MAP3K8, ITGA5, ARHGAP4 and AQP1) was constructed by multivariate Cox analysis. This evidence concerns the gene SH2D3C and head and neck squamous cell carcinoma.