HIF1A and central nervous system cancer: The region with the highest Fisher score and second highest PBS and XP-EHH scores in PNG highlanders includes the long intergenic non-protein coding RNA LINC02388. This intergenic RNA is associated with the serum levels of protein LRIG330 that impact angiogenesis – the formation of new blood vessels – in glioma cells through regulation of the HIF-1α/VEGF pathway33.