There were 253 genes (13.6%) that had decreased expression shared across tumor types (Supplementary Fig. 11C), including NPTXR, SCG2, B4GAT1, and ATRN. Genes that were decreased in expression across all tumor types were associated with the insulin receptor signaling and ion channel transport among other pathways (Supplementary Fig. 11E). This evidence concerns the gene ATRN and neoplasm.