Additionally, even among the shared differentially hydroxymethylated CpGs in the progenitor-like cell types, numerous differentially hydroxymethylated CpGs were located within different genes that regulate epigenetic patterns, such as DNMT3A, HDAC4, MLLT3, and KAT2B. Furthermore, pediatric brain cancers have been shown to contain somatic mutations in epigenetic regulator genes such as H3F3A, KDM6A, and MLL3136–138. Here, HDAC4 is linked to brain cancer.