These results suggest that photoactivation of the A2ARPAM-1 in the NAc of mice induces sleep by increasing the RMP of indirect pathway neurons expressing A2ARs. We did not analyze other behaviors after photoactivation of the A2ARPAM-1 in the NAc because A2ARPAM-1, likely due to its sleep-inducing properties, strongly suppresses behaviors such as risk-taking in an open field test in WT as well as in microtubule-associated protein 6 (MAP6) KO mice (Supplementary Fig. 9, unpaired Mann-Whitney test), a genetic mouse model of schizophrenia/psychosis10,27. The gene discussed is MAP6; the disease is schizophrenia.