Some genes that were topmost DE in glioblastoma nuclei include RMST, ID4 and PBX3. Lastly, in the Schwannoma, there were 864 downregulated genes and 813 upregulated genes relative to non-tumor tissue that were associated with elastic fibers and RHO/RAC1 GTPases cycles (Supplementary Fig. 10F, Supplementary Data 9). The gene discussed is ID4; the disease is glioblastoma.