Shared decreased protein-coding genes across all tumor types included FOXP2, GABRA1/2/4/5, NRGN, SST, and SYNPR. Even when differential gene expression analyses were adjusted for cell type, across all tumor types, there was decreased expression in genes associated with neuronal system such as transmission across chemical synapses and activation of NMDA or GABA receptors (Fig. 6C). Here, NRGN is linked to neoplasm.