Additionally, as the malignant tumor phenotype was attenuated by disitertide and enhanced by Tgfb1, CECs from NAT exhibited corresponding decreases and increases, respectively, in the mtDNA copy number; coexpression of Nd1, Cytb, and Cox1; mitochondrial ROS level; and endogenous Tgfb1 mRNA content (Fig. 8f and Supplementary Fig. 17a–c). This evidence concerns the gene BRD2 and neoplasm.