NOTCH3 and Alzheimer disease: Among the top genes/proteins dysregulated in Knight-C4, several AD biomarkers including APP, APOE, CLU, SNAP25, GFAP, SNCA, NOTCH3, TARDBP, GRN, MMP9, and C9ORF72 were identified (S3, S8, and S9 Data and Fig 5A and 5D).