They also showed higher tau tangle densities (p = 1.3 × 10−02) and neurofibrillary tangle burdens (PHF tau tangles, p = 2.1 × 10−02; S6A and S6B Fig), significantly higher astrocyte (p = 3.1 × 10−08) and lower neuron (p = 9.7 × 10−14) proportions (Fig 3F and S2 Data), and a nonsignificant (p > 0.05), trend to higher plaque densities—Global burden of AD pathology (S6C Fig, see Materials and methods and Bennett and colleagues [45] for details on how these neuropathological variables are identified). The gene discussed is MAPT; the disease is Alzheimer disease.