VGF is a secreted polypeptide and cleavage by prohormone convertases 1 and 2 generates a number of peptides with neuronal tissue-specific localization and diverse effects including modulation of neurogenesis, energy expenditure and reduced expression in spinal cord tissue and CSF of ALS patients [35,36]. The gene discussed is PCSK1; the disease is amyotrophic lateral sclerosis.