RET and hereditary neoplastic syndrome: Constitutively active RET mutants give rise to the inherited cancer syndrome multiple endocrine neoplasia type 2 (MEN2), which is characterized by the adrenal tumor pheochromocytoma (PCC), while activating mutations or increased RET expression are found in a subset of sporadic PCC (Le Hir et al., 2000; Mulligan, 2018; Takaya et al., 1996a; Takaya et al., 1996b).