Using a CRISPR TMEM127-KO in the neuroblastoma cell line SH-SY5Y, we noted significantly increased levels of endogenously expressed RET protein, which appeared primarily as the higher molecular weight fully glycosylated form found at the cell surface (Richardson et al., 2006; Richardson et al., 2012; Takahashi et al., 1991). This evidence concerns the gene RET and neuroblastoma.