To directly compare the functions of AR-V7 and AR-FL in bone metastasis, we generated 2 lentiviral stable lines expressing doxycycline-regulated V5-tagged AR-V7 (C4-2-tet-ARV7) or AR-FL (C4-2-tet-ARFL) using the C4-2 PCa cell line, which was derived from castration-resistant LNCaP xenografts and does not express AR-V7 (Figure 1, A and B). Here, AR is linked to posterior cortical atrophy.