We integrated transcriptomic data with cellular data — including immunophenotyping of rested and PfSPZ-stimulated PBMCs and frequency of CSP-specific B cells — and plasma cytokines to determine significant monotonic relationships with postvaccination CSP-specific IgG and 6-month time-to-parasitemia outcomes across all groups. This evidence concerns the gene DNAJC5 and parasitic infectious disease.