TNF and malaria: Baseline myeloid and innate inflammatory signatures (monocytes, myeloid DCs, low-density neutrophils, “TLR and inflammatory signaling”, “TNF signaling via NF-κB”) were enriched in NP for 1.8 × 106 PfSPZ infants and the VRC trials of malaria-naive adults but, conversely, enriched in P for the BSPZV1 trial of malaria-experienced adults (Supplemental Figure 4, B and C).