The most advanced malaria vaccines, RTS,S and R21, are subunit vaccines composed of an immunodominant B cell epitope (asparagine-alanine-asparagine-proline [NANP] repeats) and T cell epitopes from the P. falciparum (Pf) circumsporozoite protein (CSP) fused to hepatitis B surface antigen. The gene discussed is DNAJC5; the disease is malaria.