The soluble factors derived from CH-hMSCs and PL-hMSCs decreased the expression levels of several pro-tumorigenic genes, including cell cycle activators (CyclinD1, E2F1, E2F2, and MYC), components of NF-kB signaling pathway (NFKB1, NFKB2) and components of Notch signaling pathway (NOTCH1, NOTCH2) that are highly activated in GBM cells [27,28], the GBM stem cell marker PROM1 [29,30], and ITGA1 that play a role in GBM drug resistant [31] (Figure 5). Here, E2F1 is linked to glioblastoma.