This discrepancy is probably caused by the difference in the sources of hMSCs used in each study, since other previous studies showed that soluble factors derived from Ad-MSCs enhanced C6 rat glioma cell migration and promoted their EMT [64], and soluble factors derived from glioma-associated hMSCs (gaMSCs) induced EMT and increased U87 cell migration by up-regulating FOXS1 expression [65]. This evidence concerns the gene FOXS1 and central nervous system cancer.