To investigate the mechanism behind EIF3B knockdown blocking cholangiocarcinoma progression, we conducted a PrimeView Human Gene Expression Array on shCtrl/shEIF3B-transfected HCCC-9810 cells, identifying 402 upregulated and 442 downregulated genes in the shEIF3B group (Figure 3A). This evidence concerns the gene EIF3B and cholangiocarcinoma.