In lung adenocarcinoma cells, high expression of progesterone membrane receptor α (MPRα) increases HIF1α-induced secretion of VEGF-A into the media, which promotes the migration and tube formation of human umbilical vein endothelial cells (HUVECs) (Qin et al. 2020; Xia et al. 2022). This evidence concerns the gene VEGFA and lung adenocarcinoma.