Biological processes such as postsynapse organization, cognition, and locomotory behavior were enriched in genes (Mapt, Gabrb3, App, Ppp3cb, and Slc8a2) (Table S6) with directional coherence for Plcg2*M28L human AD changes in Consensus Cluster C (Figure 4C, Table S5). The gene discussed is APP; the disease is Alzheimer disease.