The ID and MR tumors (those exhibiting the most immunologically cold phenotypes and associated with worse outcomes) had the highest level of tumor B7-H4 expression (Fig. 1B and C), though in contrast to prior findings (25, 49), B7-H4 was also present in FI tumors, possibly due to the selective or direct molecular effects of NAC in this cohort. Here, VTCN1 is linked to neoplasm.