Th2 cells secrete inflammatory cytokines driving B cells to produce more IgE, which would bind to mast cells to produce a series of inflammatory mediators such as leukotrienes, endothelin, prostaglandin and thromboxane A2, etc. The increased IgE eventually induces rapid onset allergies and chronic airway inflammation.30, 31, 32. The gene discussed is IGHE; the disease is Allergy.