KRT40 and progeroid syndrome: NAT10‐mediated α‐tubulin (K40) acetylation (Ac‐α‐tubulin) enhances microtubule stabilization, thereby disturbing the nucleocytoplasmic shutting of cargos and causing cell dysfunction, and inhibition of NAT10 ameliorates aging features and promotes healthspan in progeria mouse model (Balmus et al., 2018; Larrieu et al., 2018).