In both cohorts, incremental GLP-1 increased with increasing age, insulinsensitivity, and HDL cholesterol, and reduced with increasing adiposity (BMI, waist, andliver fat) (Supplementary Table S3 (17)).After adjustments, the incremental GLP-1 decreased with glycemic status in cohort 1 (10.2%reduction in IGT and 15.5% reduction in SD-DM) (see Fig. 1). The gene discussed is GLP1R; the disease is diabetes mellitus.