This is in agreement with a twin cohortstudy showing that in the context of acquired obesity, lower incremental GLP-1 secretionis associated with higher adiposity and decreased insulin sensitivity (31), and the ADDITION-PRO study showing that inpeople with prediabetes a higher incremental GLP-1 was associated with lower adiposity(BMI and waist circumference) and better insulin sensitivity (5). This evidence concerns the gene GCG and prediabetes syndrome.