We aimed to investigate the associations of fasting total GLP-1 and incremental GLP-1(calculated as postprandial 60 minutes total GLP-1 minus fasting total GLP-1) with diet,lifestyle, and cardiometabolic parameters in 2 deeply phenotyped cohorts from the InnovativeMedicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) Consortium(https://directdiabetes.org) (11): cohort 1, those at risk of T2D; and cohort 2,new-onset T2D. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.