The role of glucose-stimulated release of GLP-1 in thedevelopment and physiology of type 2 diabetes (T2D) remains controversial (3, 4).A recent large cohort study provided evidence that the postprandial secretion of GLP-1 isreduced in individuals with T2D and obesity (5).In contrast, a meta-analysis comparing GLP-1 in people with diabetes and weight-matchedcontrols found the incremental concentrations of GLP-1 did not differ between groups and wereunaffected by weight (4). This evidence concerns the gene GLP1R and obesity due to melanocortin 4 receptor deficiency.