Subjects with variant genotype (GG) for A23G polymorphism had an elevated risk for lung cancer (OR = 2.56; 95% CI 1.49–4.39; p = 0.0007). For XPA codon 228 polymorphism, the heterozygous genotype (GA) showed a significant protective effect (OR = 0.54; 95% CI 0.38–0.78; p = 0.001). Here, XPA is linked to lung carcinoma.