E2F1 and neoplasm: E2F1 and E2F8 expression is also enriched in PDAC and the majority of E2F1 and E2F8 producing cells are malignant ductal cells suggesting that E2F transcription factors may also participate in PDAC tumor formation similar to what has been observed in tumorigenesis and treatment resistance of colon, breast, and cervical cancer.39, 40, 41