Our data indicated a downregulation of hyperglycaemia‐induced αSMA by Sirt7 overexpression supplemented with glucose normalization, which increased the hyperglycaemia‐mediated reduction of HIC1, SDC1 and CD31 expression in the kidneys of the rats, while insulin alone did not work (Figure 7A). This evidence concerns the gene ACTA1 and Hyperglycemia.