FKBP5 and asthma: In the recent U-BIOPRED bronchoscopy study25, ICS-inducible genes such as FKBP5 were upregulated in severe asthma, suggesting that their participants were adherent to treatment, and importantly, that ICS transactivation appears to be preserved in severe asthma, but many pathological pathways that should be sensitive to transrepression by ICS such as T2 signalling are not responsive in a subset of patients8,9,24.