By identifying genes with differential expression, building a WGCNA network to identify gout-related mRNAs, and inputting these overlapping mRNAs into the STRING database to construct a protein interaction network, the Mcode module analysis and the cytoHubba_MCC algorithm identified CXCL8, CXCL1, CXCL2, IL-1β, and IL6 as important biomarkers. Here, CXCL1 is linked to gout.