In contrast, immune complex-mediated anaphylaxis most likely contributed to the severity of these reactions on day 21 and onward, which is when we observed the initial detection of ICs (Figure 2A), a nearly 8-fold increase in CD45+ASNase+ cells (Figure 1B), IC-mediated basophil activation (Figure 1D), and a corresponding ≥ 3.5-fold increase in the severity of anaphylaxis relative to day 17 or 19 (Figure 1A). Here, PTPRC is linked to anaphylaxis.