Biomarkers objectively assess biological processes, normal, pathological or in response to a given intervention (50) and are instrumental in the diagnosis and monitoring of peri-implant diseases (51).The cells of the gingival epithelium, fibroblasts, neutrophils and macrophages, release cytokines, such as IL-6, IL-1β and NFα, which cause the degradation of connective tissue and alveolar bone, and about 100 different molecular components have been evaluated in the diagnosis of potential periodontal diseases, although for the diagnosis of peri-implantitis, this number is reduced to half. The gene discussed is IL6; the disease is Peri-Implantitis.