IL-6 also induces bone resorption and, moreover, acts synergistically together with IL-1β, and it has been shown that the levels of both cytokines in peri-implant gingivocrevicular fluid (PGF) are higher in areas with peri-implantitis than in healthy areas (25), although cytokine levels in healthy areas are not perfectly defined (26). The gene discussed is IL1B; the disease is Peri-Implantitis.