Biofilms together with the breakdown products of peri-implant bone tissue, in the case of peri-implantitis, appear to result in a local immune response in the infected tissue and the production of proinflammatory cytokines such as IL-1β, associated with the stimulation of fibroblasts, endothelial cells and osteoclasts (24). This evidence concerns the gene IL1B and Peri-Implantitis.