The KEGG enrichment analysis revealed that these aging-related genes in heart failure were significantly enriched in pathways including Cellular Senescence, Proteoglycans in Cancer, Cell Cycle, MicroRNAs in Cancer, C-type Lectin Receptor Signaling Pathway, PI3K-Akt Signaling Pathway, and various cancer-related signaling pathways. Here, AKT1 is linked to heart failure.