Atherosclerotic plaques from patients who suffered a myocardial infarction as well as those with unstable angina similarly contain autoreactive CD4+ CD28- T cells, while the expansion of CD4+ CD28- T cells has been attributed to an increased cytotoxic affinity towards endothelial cells in acute coronary syndromes (113–116). The gene discussed is CD4; the disease is acute coronary syndrome.