In primary THSD7A-positive MN patients, serum THSD7A antibody IgG subtypes are mainly IgG4; multiple studies have reported that there is no statistically significant difference in the level of THSD7A antibody IgG subtype between sera from THSD7A-positive MN patients with or without malignant tumors (10, 15). Here, THSD7A is linked to cancer.