We conducted the review through PubMed and Google Scholar in July 2023 using keywords such as “pediatric glioblastoma”, “tumor biomarkers”, “multi-omics integration”, “tp53 mutations”, “IDH mutations”, “epigenetic alterations”, “non-invasive biomarkers”, and “imaging biomarkers” for articles on pediatric glioblastoma biomarkers. The gene discussed is IDH2; the disease is glioblastoma.