NADP: nicotinamide adenine dinucleotide phosphate, IDH: isocitrate dehydrogenase, GBM: glioblastoma multiforme, WHO: World Health Organisation, IDH-TET: isocitrate dehydrogenase-ten eleven translocation, 2HG: 2-hydroxyglutarate, HGG: high grade glioma, p53: tumor protein, LFS: Li-Fraumeni syndrome, TP53: tumor suppressor gene, RNA: ribonucleic acid, MiR/miRNA/miR: micro ribonucleic acid, GDP: group lasso regularized deep learning for the survival prediction in cancer patients, IR: insulin resistance. This evidence concerns the gene TP53 and central nervous system cancer.