In the process of cancer development, the short-term effects mainly occur at the plasma membrane level and involve membrane transport systems including the transporters for glucose and amino acids, the Na+/K+-ATPase activity, the Na+/H+ exchanger, and kinase activities such as Mitogen-Activated Protein Kinase (MAPK) and Phosphatidyl Inositol 3 Kinase (PI3K), therefore increasing angiogenesis and the growth of tumor cells (18). Here, WNK2 is linked to neoplasm.