Finally, to establish whether circulating adipokines might influence the development of brain infarcts in this cohort of 508 MCI and AD subjects, we conducted a multivariable fractional polynomial Cox regression analysis with age, gender, baseline leptin and adiponectin levels, BMI, hypertension and ApoE4 carrier status as predictors (Table 4). The gene discussed is ADIPOQ; the disease is hypertensive disorder.