To establish which are the variables that could be associated with baseline serum leptin levels in our population, we performed a multivariate regression analysis for leptin levels in our disease group (MCI and AD), building a model that included age, gender, diagnosis, BMI, ADAS-Cog, MMSE, dyslipidaemia, hypertension and brain infarcts. This evidence concerns the gene LEP and inherited lipid metabolism disorder.