SPRY4 and neoplasm: Additionally, several microRNAs, such as miR-411-5p (rhabdomyosarcoma), miR-411 (non-small cell lung cancer), miR-18a (non-small cell lung cancer), miR-92a (non-small cell lung cancer), miR-1908 (glioma), and miR-181 (breast cancer), downregulate SPRY4 by directly targeting and degrading SPRY4 transcripts in various cancer cells, promoting tumor occurrence and development (54, 60–63).