Consistent with previous results, researchers found that overexpression of SPRY4 induces apoptosis in human colorectal cancer cell lines (SW480), increasing the apoptotic rate, upregulating the expression of pro-apoptotic proteins (Bax, Cleaved Caspase-3), and downregulating the expression of anti-apoptotic proteins (Bcl2 and EZH2) (8). Here, SPRY4 is linked to colorectal cancer.