These developmental and structural abnormalities manifest as behavioral disorders, including intellectual impairment, speech development delay, seizures, impaired motor function, social-behavioral deficits, and cognitive deficits which are observed phenotypes in human patients with Zmiz1 de novo mutations and correlate to ASD patients (3, 9, 10, 47–49, 82–87). The gene discussed is ZMIZ1; the disease is Atypical behavior.