PDK1 and pancreatic neoplasm: Casari et al. [146] identified novel 2-oxo-indole derivatives in a panel of pancreatic cancer cell lines and examined them for dual inhibitory effect towards PDK1 and Aurora kinase A. In the PDK1 inhibition experiment, compounds 45 and 46 displayed IC50 values of 0.11 and 0.41 μM, respectively.