As mentioned above, we still need more experiments to confirm the effects of Circ_0003855, miR-622, and FLOT1 on EC and the relationship among them (such as dual luciferase reporter, immunoprecipitation, etc.), as well as to further confirm the changes in tumor growth in vivo after interfering with Circ_0003855 expression. The gene discussed is FLOT1; the disease is neoplasm.