RHOBTB2 and Miyoshi myopathy: Broyl et al. [23] used a panel composed of 3404 SNPs to analyze 186 MM patients treated with bortezomib induction therapy and found that RHOBTB2 an enzyme-encoding gene involved in drug-induced apoptosis, the CPT1C gene involved in mitochondrial function, and the SOX8 gene involved in peripheral nervous system development are associated with early-onset BIPN.