Warburg effect’s new strategy for tumor treatment includes targeting the HIF-1α Signal pathway to regulate HIF-1α and its downstream effector molecular level, targeting oncogenes and tumor inhibitor genes to change the metabolic mode of cancer cells, directly interfering with aerobic glycolysis to block the energy supply of tumor cells, and targeting the acidic microenvironment to inhibit tumor invasion and metastasis [45,46]. This evidence concerns the gene HIF1A and cancer.